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As you age, your cells slow glutathione production

For example, antibiotics that induce ROS, like -lactams or aminoglycosides, often cause bacteria to up-regulate the pentose phosphate pathway for NADPH production, which feeds GSH

Markedly reduced hepatic SOD activity has also been observed in many other diet-induced animal MASLD/MASH models, such as animals with a methionine-choline deficient diet, an iron-rich diet, monosodium glutamate (MSG)-induced obesity, lipopolysaccharide-induced liver injury as well as CCl 4 -induced liver injury (Alfarisi et al