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In ovarian cancer, tumor cell-derived exosomes carrying CMTM4 are taken up by macrophages, promoting TGF-1 and CXCL12 secretion via NF-B pathway activation and enhancing ICAM1/CD206-mediated M2 polarization, thereby reducing the efficacy of PD-1 inhibitors (203)

CFS points out that the studies supporting the safety of genetically engineered soy leghemoglobin included authors who work for Impossible Foods, which is a conflict of interest