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Could too much B12 actually harm the kidneys

However, these changes did not reach a significant level compared to the placebo group

In the UK, the standard NHS regimen for B12 deficiency without neurological involvement is hydroxocobalamin 1mg IM three times a week for two weeks

Doctors usually give it as a course, not just once

Early signs of declining B12 levels include profound fatigue, tingling or numbness in extremities, cognitive changes, and balance problems requiring medical review