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Among this metabolic conversion, iso-astaxanthin (4, 4-dihydroxy-, -carotene-3, 3-dione) was the key intermediate [60]

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Thus, hypoxia-generated ROS represents a fundamental pathogenic mechanism contributing to chemoresistance [480], ischemiareperfusion injury [481], chronic inflammation [482], and neurodegeneration [483]

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This includes choosing organic produce when possible, using clean household cleaners, and minimizing alcohol consumption