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The methionine-sparing effect of cystine

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Pharmacological inhibition of GPX4 accelerates motor neuron degeneration and death (366, 367, 369), whereas GPX4 overexpression delays disease onset, improves motor function, and prolongs survival (368, 371)

At the molecular level, 6-hydroxydopamine treatment has been observed to increase the levels of mRNA for Il-6 , Tnf- , and NF- , while decreasing the protein expression of GPX-1 and COX-2 in the PFC [101]

In this synthesis process, cysteine (Cys) is the limiting substrate and its cellular uptake as the oxidized form, cystine (Cyss), is mediated by the cystine/glutamate antiporter xCT (encoded by the SLC7A11 gene)