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2a) It is important to note that there is also evidence to the contrary that suggests G6PD-d may exert a vasoprotective effect by preventing pathogenic VSMC proliferation, limiting vasoconstriction, and protecting against angiotensin II-induced hypertension 45,46

Lastly, NBDHEX is not a substrate for the P-glycoprotein export pump but promotes cysteine-dependent apoptosis in cells overexpressing P-gp and may be used to treat P-gp-positive tumors [165]