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Figure 1 Nutritional support in patients with cancer cachexia aims to counteract the negative energy balance as well as the net protein breakdown, without stimulating tumor growth or negatively influencing anti-tumor therapy

The majority of scholars concur that elevated levels of LCACs are associated with insulin resistance and that their accumulation can be employed as a biomarker of insulin resistance [72]

Mitochondrial dysfunction: metabolic disruption, energy crisis and oxidative stress MMAemia is caused by defects in MMUT or its coenzyme Cbl, leading to toxic accumulation of primary metabolites (MMA, 2-MCA, PA, and Hcy) and secondary metabolites (ammonia and lactate) (Longo et al

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