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What drives this process

When symptoms do appear, they include: excessive panting at rest, reduced exercise tolerance and enthusiasm for activity, intermittent coughing, unexplained weight loss, and in advanced cases, a distended abdomen from fluid accumulation

The development of individualized biomarkers (e.g., GABA/Glu ratios via MRI) and precision therapies (e.g., gene editing, stem cell-based interventions) could refine diagnostic and treatment strategies