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In a healthy gut microbiota, beneficial bacteria genera such as Bifidobacterium and Lactobacillus are the dominant populations, which play important physiological roles by maintaining the integrity of the gut barrier, promoting the metabolism and absorption of nutrients, and regulating the hosts immune homeostasis (11)

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Hesperidin may inhibit P-glycoprotein cellular pumps, increasing the bioavailability of drugs and raising the risk of adverse effects