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These are applications where the regulatory pathway is shorter, the safety bar is lower (topical and ophthalmic versus systemic), and the commercial route does not require a full drug approval for systemic use

Ariza ME, Rivailler P, Glaser R, Chen M, Williams MV

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Epitalon also influences the neuroendocrine system by stimulating nocturnal melatonin release from the pineal gland, thereby normalizing circadian hormone rhythms in aged subjects [3]