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Subsequent single-cell sequencing and bulk transcriptome analyses demonstrated that glutathione metabolic reprogramming remodels the tumor immune microenvironment by modulating key transcription factor activities, altering cellcell communication networks, and promoting CD8 + T cell exhaustion

Metz, A

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Saikosaponin d modulates the polarization of tumor-associated macrophages by deactivating the PI3K/AKT/mTOR pathway in murine models of pancreatic cancer