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173 Therefore, malignant cells shift from undertaking mitochondrial oxidative phosphorylation (OXPHOS) to invoking the glycolysis pathway, even under normal oxygen conditions with full and proper mitochondrial functioning, creating a pseudohypoxic state known as the Warburg effect

This process results in mutations, particularly in critical tumor suppressor genes like TP53, significantly elevating the risk of bladder cancer (Vineis and Pirastu, 1997

This method is suitable for analysis scenarios that focus on the strongest gene expression across samples

All these mechanisms lead to MS-like motor symptoms observed in patients with Cbl deficiency such as subacute degeneration of the spinal cord [84]