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Slater SK, Nelson TD, Kabbouche MA, et al

Getting the proper amount of Vitamin B12 into your body will help lift your mood and may lessen feelings of depression

B1 (niacin) is known to cause flushing I believe

367,520 Duloxetine relieves pain by increasing the synaptic availability of serotonin and norepinephrine in descending pathways, enhancing endogenous pain modulation