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Microglial activation was observed at 10 months, but no neuronal loss was noted

10.1016/s0300-483x(98)00120-6 Toxicology

In the pre-metastatic niche of colon-rectal cancer (CRC) cells, the exosomal miR-25-3p was transferred to endothelial cells to promote vascular permeability and angiogenesis [76]

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These alterations shift the E/I ratios toward excitation, as quantified by: Reduced GABAA receptor clustering in hippocampal neurons Enhanced glutamatergic synaptic transmission Impaired long-term potentiation (LTP) thresholds This imbalance of E/I affects most of the neurodevelopmental mechanisms involved, such as synaptic pruning and network remodeling, which form the basis of the behaviors associated with ASD, such as sensory hypersensitivities and impaired social affairs [133]