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It is well known that vasodilatory renal prostaglandins and the potent vasoconstrictor angiotensin II work in concert to maintain renal blood flow

Instead of just targeting a single spot, youre now looking at a compound that can influence the entire GI tract, from the esophagus to the colon, and then be absorbed into the bloodstream to work throughout the body

It upregulates genes involved in tissue remodeling, like collagen I and III production, while downregulating pro-inflammatory pathways like NF-B

Sometimes because placebo effects in early human trials were stronger than expected

Bone marrow transplantation : Sometimes, a bone marrow transplant is considered a cure