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We know that various areas of the brain can alternatively function in terms of their energetic requirement with using ketones as substrate

Thieme, 1977

Deficiency of GPx results in direct tissue damage and activation of age-related NF-B inflammatory pathways [57]

A defining feature is the dual role of autophagy, which can either suppress or induce ferroptosis depending on the genetic background, LC subtype and microenvironmental cues