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Many studies, both in vitro and in vivo reported melatonin as a very good scavenger of free radicals, especially in cancers, neurodegenerative disorders, and psychiatric diagnosis

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Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (Vinciguerra et al., 2020), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (Vinciguerra et al., 2020

Signals from the gastrointestinal tract can reach the central nervous system, while the central nervous system can relay signals back to the enteric nervous system [36]