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The lack of protective mucin and antimicrobial factors will therefore lead to increased frequency of bacteria penetrating into microvillous surface of enterocytes (Olsen et al., 2002

doi: 10.1126/science.aaf6284 14 MichalekRDet al

For topical applications, mild irritation, redness, or itching at the application site are the most commonly reported observations

It has been reported that when ferroptosis occurs in neurons, then microglia are activated and release toxic substances including pro-inflammatory factor IL-6, which can cause neuro-inflammation and lead to further brain damage (Tang et al., 2020)