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(vii) glutamine consumption by clear cell renal cell carcinoma in vitro leads to IL-23 secretion by macrophages and Tregs recruitment, possibly restraining antitumor immunity in humans too [189]

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Experimental approach: Thirty-three male mice were divided into five groups of 6-8 as follows: sham group (normal saline), NIC group (5 mg/kg single dose on day 7), treatment groups (CAPE at 4 and 8 mg/kg for 7 days), and diazepam group (1 mg/kg single dose on day 7)