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doi: 10.1111/j.1699-0463.1994.tb04868.x 79 HeathP

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Beyond its role as a protector, it is also a recycler

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Under oxidative stress or xenobiotic stress and increased ROS levels, Nrf2 dissociates from Keap1 and translocates to the nucleus where it binds antioxidant response elements (ARE) and activates the transcription of associated genes 50