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In a micronucleus assay in mice, aspartame was administered as a single oral dose at 2501000 mg/kg bw by gavage, and bone marrow and peripheral blood samples were obtained at 24, 48, or 72 hours after dosing

(Do not wait for assay results to begin acetylcysteine treatment.) 2

5 Conclusion and Perspectives Dysfunction of the tumor suppressor p53 has a widespread impact during carcinogenesis

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In the development of BP, the increased presence of Th2 cells and IL4 in the bloodstream promotes the growth of B-cells, triggers the generation of antibodies, and facilitates the switching of immunoglobulin classes