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If these conditions are severe or left untreated, they can cause lifelong nerve damage or even death

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Further, the loss of Hb by use of a novel T-lymphocyte-specific Hb knock-out mouse impairs mitochondrial function, dysregulates cytokine production, and lowers the activation threshold primarily in CD4 + T-lymphocytes, indicating a critical role for Hb within this subset

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However, minor genetic effects are not excluded by this study