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An unconventional mechanism of IL-1 secretion that requires type I IFN in lupus monocytes

Kardon, T., Stroobant, V., Veiga-da-Cunha, M

Experimental study demonstrates that LDN induces a phenotypic shift in BV-2 microglial cells, transitioning them from a pro-inflammatory(iNOS high CD206 low ) to a quiescent, anti-inflammatory M2 state (iNOS low CD206 high ) [150]