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Physiol Rev 90(1):207258 Marin-Garcia J, Goldenthal MJ (2002) Fatty acid metabolism in cardiac failure: biochemical, genetic and cellular analysis

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Butyrate also provides direct anti-inflammatory benefits by inhibiting key pro-inflammatory signaling pathways, thereby counteracting cytokine-driven disruption of tight junction integrity

Cyclosporine A (CsA) was introduced as an mPTP inhibitor, acting indirectly by inhibiting cyclophilin D (CypD) to prevent pore opening