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Reducing the availability of endogenous copper and glucose for cascade starvation therapy and chemodynamic therapy

Results: After excluding 2 cases with unreliable VCTE measurements, VCTE and MRE identified the following stage distributions: F0-F1 (n=32 vs 69), F2 (n=20 vs 9), F3 (n=15 vs 14), and F4 (n=36 vs 11) with statistically significant differences in distribution for F0-1 (p value 11.2), LSM ( 15 kPa), FIB-4 ( 2.67), and histology (F2, F3, F4) to assess the risk of occurrence of the primary outcome

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Braaks hypothesis suggests that the -synuclein pathology begins in the ENS and then migrates to the brain, passing through the brainstem, midbrain, basal forebrain, and finally the cortical areas [118, 119]