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Due to the advancement of biological tools, wet lab work has improved in past decades, improving the effectiveness between target and compound 11

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Abstract Multiple target inhibition has gained considerable interest in combating drug resistance in glioblastoma, however, understanding the molecular mechanisms of crosstalk between signaling pathways and predicting responses of cancer cells to targeted interventions has remained challenging

These data suggest that the functional Affimer motif responsible for binding and inhibition of KRAS is small, in agreement with the total interacting surface interface estimated by PISA analysis 29 of 478.3 2 for the K6:KRAS complex, a substantially smaller area than most common protein-protein interaction surfaces

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