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Developed by Novo Nordisk, this long-acting amylin analogue works by activating amylin receptors throughout the body, particularly in areas that regulate appetite and digestive function [1]

Given the benefits of tirzepatide on weight, waist circumference, and lipid parameters in addition to impressive improvements in glycaemic control, this medication appears to be ideally placed as first add-on therapy for individuals not at HbA1c target on metformin, particularly for those with T2D and excess adiposity (Table 2, clinical scenario A)

Pramlintide is a short-acting amylin analog, which cagrilintide already covers as a long-acting version