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Drugs demonstrated to be CYP3A inhibitors on the basis of clinical studies involving alprazolam: nefazodone, fluvoxamine, and cimetidine [see Drug Interaction (7.1), Clinical Pharmacology (12.3)]

Co-resistance arises when different genes present in the same genetic element confer resistance to multiple agents at once, and are often found in mobile genetic elements (plasmids, transposons, or integrons

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[DOI] [PubMed] [Google Scholar] Hockenberry M.J., Hooke M.C., Gregurich M., McCarthy K

Additionally, IGF-1 LR3 is investigated for its interaction with insulin-like growth factor binding proteins (IGFBPs), which regulate peptide availability and receptor engagement