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Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

In HCV patients, treatment was initiated as soon as possible and the follow-up was stopped after SVR, except in cirrhotic patients

In this study, the authors show that it is not the mitochondrial ATP production, but the uninterrupted flux through the TCA cycle, enabled by the low NADH/NAD + ratio, is the major limiting factor for cell proliferation

Moreover, enhanced tolerance to various abiotic stresses was observed in plants over-expressing DHAR (Kwon et al., 2003

Age-associated remodeling of T cell immunity and metabolism