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Bigwigs were made using genomeCoverageBed from bedtools 2.17.0 and wigToBigWig from the UCSC toolkit after scaling per 10 million reads mapping onto exons (30, 31)

Cells were seeded and grown to a confluency of approximately 90% and treated for 90 min with either DMSO vehicle or EN25 before harvest and lysis

Both continuous and single-dose administration have shown clinical efficacy, with a favorable safety profile

She is a graduate of the University of Houston College of Pharmacy and served as a PCCA PharmD Resident for one year post-graduation, which included a teaching position at her alma mater

Combined administration of L-buthionine sulfoximine (BSO), as a glutathione depletory agent, caused a dramatic change in methimazole-induced hepatotoxicity characterized by hepatic necrosis and a severe elevation of serum ALT activity