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e detrimental eects of B12 deciencysuch as hyperhomocysteinemia and impaired methylationare well-established and can negatively impact oocyte qual- ity and embryo viability [19, 20], which is consistent with the lower pregnancy rates we observed at low B12 lev- els

however, it is unclear whether this a direct effect of 5-ASAs or owing to benefits related to mucosal healing[26]

For comparison within the groups before and after treatment, we used the paired t test

It is needed to produce methylfolate, which recycles homocysteine, produces SAMe and recycles biopterin, all extremely important nutrients in the body

The remaining nine vitamins are water-soluble, meaning the body excretes any unused leftovers