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Nat Rev Neurosci 2015;16:64759

The initial list of candidates for DDI prediction included the six CYP2C19 inhibitors that are most frequently co-prescribed with S-CIT: esomeprazole, cimetidine, lansoprazole, fluconazole, omeprazole, and fluoxetine

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Co-crystal structure of 7b in complex with KRAS G13C mutant To further characterize the novel nucleotides with the cyclic linkers, KRAS G13C was co-crystallized with compound 7b to obtain detailed structural insights into ligand binding within the binding pocket (resolution:1.85 , R work : 18.98, R free : 22.78