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Pusponegoro et al

Furthermore, vitamin D can inhibit ferroptosis by activating the vitamin D receptor, which in turn upregulates the NRF2/HO-1 signaling cascade, as shown in in vitro and in vivo models (73)

This is particularly interesting because it demonstrates FOXO4-DRI's senolytic activity extends to endocrine tissues and can restore hormonal function, not just structural tissue integrity