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The authors also reported that mouse embryonic fibroblasts of PAD4 knockout mice showed increased FUS aggregation and sequestration into SGs compared with PAD4 overexpression cells, indicating that citrullination inhibits FUS phase separation 113

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Glutamine is a key component in energy production and immune activation, with increased lymphocyte levels such as CD4+ T cells activated through receptors and CD28 [138]

BoschAMAbelingNGIjlstLKnoesterHvan der PolWLStroomerAEet al

Hence the decrease in GSSG is in keeping with GPX1 being one of the major enzymes that uses GSH as an electron donor to generate GSSG