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43, 57 The effect of NAC is independent of GSH because in the presence of BSO+L-PAM, NAC did not increase GSH levels

ZhouHLuJLiuLBernardDYangCYFernandez-SalasEet al

Pro75 hTrx1 has been shown to prevent metal binding by the reactive thiolate-based active site 29 , and residues Glu70 hTrx1 and Lys72 hTrx1 are required for procaspase-3 affinity 30