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A more holistic approach to treating mental or mood disturbance might include a wide range of investigations, such as testing for food allergies, testing for exposure to or accumulated neurotoxins, testing for bacterial pathologies, checking for evidence of a compromised microbiome, and a whole host of valid therapeutic pathways to explore

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The unfolded protein response (UPR) alleviates ER stress through negative feedback mechanisms, which include degrading mRNA, decreasing protein synthesis, inhibiting translation, and posttranslational processes, and facilitating the transport of misfolded proteins to the cytoplasm for degradation [47]

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