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17 The downstream target of phophorylated EIF2S1 is ATF4, and knockdown of ATF4 expression can induce autophagy

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Single or repeated administration of therapeutic (15-60 mg/kg) APAP doses to mice produces detectable levels of NAPQI in the lung, and increases neutrophil numbers, myeloperoxidase activity, and cytokine and chemokine levels in the airways or skin