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Methylfolate provides the biologically active form without requiring DHFR conversion and may therefore be preferable where reduced enzyme activity is suspected

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Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S et al

This study was supported by the Ningxia Natural Science Foundation (2023AAC03560, 2018AAC03133), National Natural Science Foundation Incubation Project of General Hospital of Ningxia Medical University, the National Natural Science Foundation of China (82274014), and the Basic Research Program of Jiangsu (BK20243061, BK20232035)