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Melatonin could resolve hyper-inflammatory conditions in COVID-19 and PASC by down-regulating proinflammatory cytokines (i.e., TNF-, IL-1, IL-6, and IL-8) and increasing anti-inflammatory cytokines such as IL-10 660,661

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We speculated this phenomenon as the endogenous activation of Nrf2 signaling in cells under MPP + stimulation to resist oxidative stress, but this protective process did not reverse the damage

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Activity must be appropriately loaded, not either absent or excessive: Complete rest prevents the mechanical stimulus that signals the tendon to rebuild with the appropriate architecture