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Example weekly schedule (30mg vial) Week 1: 2.5mg dose Reconstitute 30mg vial with 3ml water Monday: Inject 0.25ml (25 units) Vial contains 29 doses of 2.5mg remaining Refrigerate, use over next 11 weeks Week 2-4 : Continue 0.25ml weekly Week 5 : Increase to 0.5ml (50 units) for 5mg dose Week 9 : New vial or continue (depending on dose progression) Dosing 40mg vials 40mg vials are bulk option

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3.3 AITD and other adverse pregnancy outcomes After analyzing 35 studies, we found that TPOAb-positive women had a higher risk of premature birth than TPOAb-negative women