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Atherosclerosis, inflammation and the accumulation of lipids in the inner layer of blood vessel walls lead to vascular blockage and contributes to the development of coronary heart disease, cerebrovascular disease and peripheral arterial vascular disease, and is associated with significant clinical morbidity and mortality rates (57)

Nucleotide excision repair (NER) eliminates a series of helix-distorting lesions that are mostly induced by UV irradiation, 76,77 whereas base excision repair (BER) primarily acts on the modification of oxidative bases, 78,79 and mismatch repair (MMR) scans for incorrectly inserted nucleotides during replication

OKeefe SJ, Li JV, Lahti L, Ou J, Carbonero F, Mohammed K, et al