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Description

The objective of this study is to determine the interaction of STAT3 and FXR agonists (IV GW4064 and obeticholic acid [OCA]) in a mouse model of acute cholangiopathy and in vitro

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The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site)

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GGT activity (d) (n = 6 technical replicates from 3 independent experiments) and cell numbers (e) (n = 3 technical replicates for Cys 2 -free or n = 6 technical replicates for Control or Cys 2 -free + GSH from 3 independent experiments) for cells grown in control (208 M cystine

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