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Novel strategies under investigation include biomarker-guided therapy using circulating nitric oxide metabolites or endothelin-1 levels, and genetic profiling to identify responders to specific antihypertensive agents 48

Here, we defined a novel NRF2 target gene set linked to NRF2-dependency in cancer cell lines, and observed that a significant portion of these genes is devoid of promoter-proximal NRF2 occupancy