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The mitochondrial apoptotic pathway is further regulated by H

10.1016/j.jclepro.2018.05.028 146

The loss of insulin sensitivity of hippocampal CA1 pyramidal neurons can subsequently cause long-term Ca 2+ -dependent afterhyperpolarizations (AHPs), which can produce significant cognitive and memory impairment in the short term and throughout life, contributing to depression (122, 123)