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For the 58aa-ARF1 intermediate the AF3 prediction for residues 2-55aa of ARF1 were used and fitted into the extra density at the NAC -sandwich

Concomitant administration of drugs may increase the risk of cardiac arrhythmia [see Drug Interactions ( 7.1)]

The non-human mammals can be genetically manipulated to be immuno-compromised (e.g., SCED) or they can be treated with chemicals (drugs) and/or irradiated