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During emotional states, increased ACC activation and decreased volume have been frequently reported, linking these changes to the severity and type of depressive symptoms [27,30]

In contrast, in cells pretreated for 60 min with BCNU prior to H 2 O 2 addition, we observed no NAPstar3b response at all, consistent with our observations of genetic disruption of glutathione reductase in yeast, plants, and HEK293 cells