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Among current preventive and therapeutic strategies, probiotic interventions have gained considerable recognition as a promising option (445)

However, several hurdles still must be addressed to realize the potential applications in clinical settings, mainly due to the human populations variation of lipid metabolism [39]

In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms

For example, cancer cells upregulate the expression level of the PPP [26] , NRF2 [52] , and isocitrate dehydrogenase 1 (IDH1) [48] as backup mechanisms for NADPH production