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doi: 10.1038/s41419-021-03790-w 113 GengNShiBJLiSLZhongZYLiYCXuaWLet al

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After your initial subcutaneous injection, semaglutide begins binding to receptors throughout your body, triggering changes in appetite, digestion, and metabolism

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Notably, hepatocytes from fibrotic-like assembloids were positively enriched for gene sets related to inflammatory reactions, including tumour necrosis factor (TNF) signalling, several interleukins (IL-4 and IL-6), and NF-B, JAKSTAT and Toll-like receptor cascades (Fig