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This dual role, known as antagonistic pleiotropy, beneficially suppresses tumor initiation early in life but detrimentally increases the risk of age-related pathologies, later

( A ) Inhibition of SLC7A11 activity by erastin lowers intracellular GSH and the GSH:GSSG ratio ( n = 6)

Via activating AMPK and suppressing pro-inflammatory cytokines (IL-6 and TNF-), AC can ameliorate renal inflammation and fibrosis induced by high glucose in HK-2 cells (Ahmed et al