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In vitro analysis of human erythroid progenitor cells that underwent shRNA knockdown of HDAC1 or HDAC2 genes resulted in increased levels of -globin but without altering cellular proliferation of the cell cycle phase

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Ponugoti, Jonathan R

As above mentioned, the methyl groups generated in the one-carbon metabolism, when released from methionine cycle, are crucial for DNA, RNA, and histones methylation for epigenetic modulation (57), whose functioning is regulated by PI3K/mTOR and HIF2 pathways, the same that control SSP and one-carbon metabolism (58, 59)

J Clin Oncol 2002 Dec 1;20(23):4555-4558